That’s why our SYNAPTIC M&A process emphasizes creating partnerships that provide incentives to both parties. Learn more about Capto's SYNAPTIC M&A outcomes.Structural and functional characteristics of the two core-shell resins Capto™ Core 400 and 700, which are useful for the flow-through purification of bioparticles such as viruses, viral vectors, and vaccines, are compared using bovine serum albumin (BSA) and thyroglobulin (Tg) as models for small and large protein contaminants. Capto Core 700 resin was then effectively adapted to a rapid in-slurry pull-out approach for high-throughput purification of reovirus and adenovirus. The in-slurry purification approach offered.īoth resins are agarose-based and contain an adsorbing core surrounded by an inert shell. Although shell thicknesses are comparable (3.6 and 4.2 µm for Capto Core 400 and 700, respectively), the two resins differ substantially in pore size (pore radii of 19 and 50 nm, respectively). Because of the smaller pores and higher surface area, the BSA binding capacity of Capto Core 400 is approximately double that of Capto Core 700. However, for the much larger Tg, the attainable capacity is substantially larger for Capto Core 700. Mass transfer in both resins is affected by diffusional resistances through the shell and within the adsorbing core. For BSA, core and shell effective pore diffusivities are about 0.25 × 10 −7 and 0.6 × 10 −7 cm 2/s, respectively, for Capto Core 400, and about 1.6 × 10 −7 and 2.6 × 10 −7 cm 2/s, respectively, for Capto Core 700. Static tools form one of the EWS core areas. Adsorbed Tg further hinders diffusion of BSA in both resins. There is no other manufacturer in the world offering such a variety of products. Capto Core 700 is designed for intermediate purification and polishing of viruses and other large biomolecules (molecular weight > - 700 000) -Novel core.
#Capto core 700 iso
#Capto core iso#Ĭoromant Capto® for reduced setup and production time Coromant Capto® is a modular quick change system certified according to ISO 26623 for turning centers. Column measurements show that, despite the higher static capacity of Capto Core 400 for BSA, the dynamic binding capacity is greater for Capto Core 700 as a result of its faster kinetics. Fisher Scientific - Cytiva HiScreen Capto Core 400 for intermediate purification and virus polishing Acquista Cytiva HiScreen Capto Core 400. However, some of this advantage is lost if the feed is a mixture of BSA and Tg since, in this case, Tg binding leads to greater diffusional hindrance for BSA.
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